L Measure functions

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[http://cng.gmu.edu:8080/Lm/help/index.htm L-Measure website]
 
[http://cng.gmu.edu:8080/Lm/help/index.htm L-Measure website]
  
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== Quick Table of L Measures Functions ==
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== Quick Table of L Measures and Additional Functions(*) ==
 
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! Image
 
! Image
 
! Description
 
! Description
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| Soma_Surface
 
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| Single soma: <math>4\pi\,\!r^2</math> (surface area of sphere)
 
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Multiple soma: <math>2\pi\,\!rh</math> (external area of cylinder)
 
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| [[File:Somasurface.png|150px]]
 
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| Surface area of the soma.
 
 
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| N_stems
 
| N_stems
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| [[File:Ntip.png|150px]]
 
| [[File:Ntip.png|150px]]
 
| Number of terminal tips of a neuron.
 
| Number of terminal tips of a neuron.
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| '''Soma Features'''
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| Soma_Surface
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| Single soma: <math>4\pi\,\!r^2</math> (surface area of sphere)
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Multiple soma: <math>2\pi\,\!rh</math> (external area of cylinder)
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| [[File:Somasurface.png|150px]]
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| Surface area of the soma.
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| Skewness X, Y, Z (*)
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| Center of the soma deviation from the center of the cell (see Dimensions).
 
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| '''Dimensions'''
 
| '''Dimensions'''

Revision as of 21:15, 2 December 2011

About L Measures

L Measures is a research tool for making quantitative morphological measurements from neuronal reconstructions. There are 43 measurements including area measurements of soma, length measurements of processes, angular twists and turns of processes, calculation of the number of terminals and bifurcations, and many more.


L-Measure website

Quick Table of L Measures and Additional Functions(*)

Features Formula or Equation Image Description
N_stems n Nstems.png Number of stems attached to the soma.
N_bifs n Nbif.png Number of bifurcations of a neuron.
N_branch n Nbranch.png Number of branches of a neuron. (A branch is between two critical points or between a critical point and the tip.)
N_tips n Ntip.png Number of terminal tips of a neuron.
Soma Features
Soma_Surface Single soma: 4\pi\,\!r^2 (surface area of sphere)

Multiple soma: 2\pi\,\!rh (external area of cylinder)

Somasurface.png Surface area of the soma.
Skewness X, Y, Z (*) Center of the soma deviation from the center of the cell (see Dimensions).
Dimensions
Width w Neuronwidth.png Measured along the x-axis of a neuron.
Height h Neuronheight.png Measured along the y-axis of a neuron.
Depth d Neurondepth.png Measured along the z-axis of a neuron.
Compartment features
Type t = 1, 2, 3, or 4 Compartments are assigned four different types: 1=soma, 2=axon, 3=dendrites, and 4=apical dendrites (are dendrites that emerge from the apex of a pyramidal cell).
Diameter D Lmdiameter.png Diameter of each compartment of the neuron.
Diameter_pow D1.5 Diameter of each compartment of the neuron raised to the power of 1.5.
Length l Lmlength.png Measured length of each compartment.
Surface 2\pi\,\!rh

(area of cylinder w/o top and bottom)

Lmsurface.png Surface area of each compartment.
Section Area \pi\,\!r^2 Lmsectionarea.png Cross-sectional area of each compartment.
Volume \pi\,\!r^2h Lmvolume.png Volume of the compartments.
Taper_1: Burke Taper \dfrac{D_a - D_b}{L} Burketaper.png The change in diameter over pathlength between two critical points (the current and previous one).
Taper_2: Hillman Taper \dfrac{D_a - D_b}{D_a} Hillmantaper.png The ratio of the change in diameter to the initial diameter of two critical points. The initial diameter is usually larger.
Branch (Segment) features
Branch_Order n = 0,1,2,3... Branchorder.png Order of branch with respect to the soma starting at 0 for branches attached to soma.
EucDistance \sqrt{(x_1-x_2)^2+(y_1-y_2)^2}

Straight line distance

Eucdistance.png Straight line distance between two endpoints of a trace.
PathDistance A + B + C + D + E + ... Pathdistance.png Summation of the individual compartment distances that form a trace.
Branch_pathlength AB + BC + CD + DE + ... Branchpathlength1.png Summation of the lengths of all the compartments comprising a branch.
Contraction EucDistance\over Pathlength Contraction.png Ratio between the Euclidean distance of a branch and its path length.
Fragmentation n Fragmentation.png Total number of compartments that form a branch between two bifurcation points, or between a bifurcation point and a terminal tip.
Helix {( \overrightarrow{A} \times \overrightarrow{B} ) \times \overrightarrow{C}} \over 3(|\overrightarrow{A}| \cdot |\overrightarrow{B}| \cdot |\overrightarrow{C}|) Helicity of the branches of the neuronal tree. Needs to be at least 3 compartments long to compute the helicity.
Fractal_Dim \log EucDistance \over \log PathDistance or

(n-1) \sum e_ip_i - \sum e_i \sum p_i \over {(n-1) \sum e_i^2 - (\sum e_i)^2}

(ei is EucDistance and pi is PathDistance)

Fractal dimension metric of the branches in the dendrite trees.
Bifurcation features
Daughter_Ratio Da / Db

Da = larger daughter diameter
Db = smaller daughter diameter

Daughterratio.png Ratio between the diameter of the bigger daughter and the smaller daughter of the current bifurcation. The diameters are measured at the initial part of the branches right when they exit the bifurcation.
Parent_Daughter_Ratio Da / Dp,Db / Dp Parentdaughterratio.png Ratio between the diameter of a daughter and its father for each critical point. The diameters are measured immediately before and after the bifurcation point.
Partition_asymmetry {|n1 - n2|} \over {n1+n2-2} Compares the symmetry of the processes in terms of the number of tips on the left daughter to the number of tips on the right daughter of a bifurcation.
Rall_Power D_p^n = D_a^n + D_b^n Parentdaughterratio.png Best value that fits the equation with extreme 0-5, resolution 1/1000 over the range.
Pk {D_a^n+D_b^n} \over {D_p^n} Parentdaughterratio.png n = [0, 5]
Pk_classic {D_a^{1.5}+D_b^{1.5}} \over {D_p^{1.5}} Parentdaughterratio.png Rall power is set to 1.5
Pk_2 {D_a^2+D_b^2} \over {D_p^2} Parentdaughterratio.png Rall power is set to 2
Bif_ampl_local ϴ (in degrees) Bifamplocal.png The local angle formed right at the vertex of the branches; initial angle formed as the two daughter branches exit the bifurcation.
Bif_ampl_remote ϴ Bifampremote.png From the bifurcation, it is the angle to the tips of the two daughter branches. Angle between two branches; angle between the ends of two growing segments (in degrees) at the current bifurcation; angle between the two daughter bifurcations and/or terminal ends (whichever comes first) at the current bifurcation. (Daughter bifurcation means the next bifurcation encountered after the current bifurcation.)
Bif_tilt_local ϴ Biftiltlocal.png The smaller of the two angles between the end of the parent branch and the initial part of the daughter branches at the bifurcation; angle between the last compartment of the parent branch and the first compartment of each daughter branch at the bifurcation.
  • There are two daughter branches for each bifurcation, which gives two angles.
Bif_tilt_remote ϴ Biftiltremote.png The smaller of the two angles between the first daughter compartment of the current bifurcating father and the previous father compartment of the previous father bifurcation; angle between the last part of the previous branch and the initial part of the next branches (skipping the branch in-between).
Bif_torque_local ϴ Angle between the current plane of bifurcation and the previous plane of bifurcation; the planes are defined by the initial part of the daughter branches as they exit the point of bifurcation.
Bif_torque_remote ϴ Angle between the current plane of bifurcation and the previous plane of bifurcation; the plane of bifurcation is defined by a bifurcation and its two daughter bifurcations or terminal ends (whichever comes first).
Terminal bifurcation features
Terminal_degree n Terminaldegree.png Total number of tips each compartment will terminate into.
TerminalSegment 0 (if not terminal), 1 (if terminal) Terminalsegment.png Assigns "1" for all the compartments in the terminal branch.
Last_parent_diam D Lastparentdiameter.png Diameter of last bifurcation before the terminal tips.
Diam_threshold D Diameterthreshold.png Diameter of first compartment after the terminal bifurcation leading to a terminal tip; initial diameter of the branch exiting the terminal bifurcation.
HillmanThreshold 0.5P + 0.25D1 + 0.25D2

P: parent diameter,
D1 = 1st daughter diameter,
D2 = 2nd daughter diameter

Parentdaughterratio.png Computes the weighted average diameter between 50% of father and 25% of daughter diameters of the terminal bifurcation.
Hausdorff ... Hausdorff dimension is a fractal dimension using the box counting method. Count the number of boxes required to cover the set.

Note: Branches are modeled as a series of compartments. Critical points refer to bifurcation points and terminal tips.

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